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British Transport Police, which took the lead on the response given it is responsible for security matters on the trains, said "multiple people" were stabbed on the Doncaster to London King's Cross train as it headed into Huntingdon. It did not provide a motive for the attack.
The East of England Ambulance Service said it had mobilized a large-scale response and that "multiple patients" were hospitalized.
Cambridgeshire Constabulary, the local police force, said armed police attended after officers were called to the scene at Huntingdon station at 7:39 p.m. on Saturday. It added that the two people were arrested at the station, which is around 75 miles (120 kilometers) north of London.
British Prime Minister Keir Starmer said his "thoughts are with all those affected" after the "appalling incident."
Paul Bristow, the mayor of Cambridgeshire and Peterborough, said he had heard of "horrendous scenes" on the train.
London North Eastern Railway, or LNER, which operates the East Coast Mainline services in the U.K., confirmed the incident had happened on one of its trains and urged passengers not to travel because of "major disruption."