The majority of these items were wipes, discovered in known blockage hotspots across the East of England.
The water company reported an average reduction of 58 per cent in expected blockages across their hotspots compared to other areas.
This news coincides with the start of Unblocktober, a month-long campaign aimed at improving the country's drains, sewers, and watercourses by educating the public on items that should not be put down the drain.
The company's blockage reduction initiative operates in areas with high blockage rates, monitoring the sewer network to prevent spillages and pollution.
Connor Brailsford, programme manager at Anglian Water, said: "Stopping fats, oils, and grease at the source is one of the most effective ways to protect our environment - especially when combined with action on unflushable items like wipes.
"That's why we're working in blockage hotspots across our region to raise awareness and protect local communities by keeping their pipes safe from blockages.
"We're really pleased that the work we're doing is already having such significant positive impacts - but there's always more we can do, and we need our customers' support."
Anglian Water identified wipes, fats, oils, grease, and other non-flushables as the primary culprits, responsible for 80 per cent of sewer flooding and 67 per cent of pollution.
Each day, around 500,000 wipes are flushed into the East of England's sewers.
To combat this, Anglian Water has deployed "hedgehog" devices in sewers to capture wipes and other unflushable materials.
These devices collected 18,071 unflushables in just eight weeks across the hotspot locations.
The company has collaborated with Environmental Compliance and Services (ECAS) to tackle commercial sewer misuse, preventing an estimated eight million litres of fats, oils, and grease from entering the sewer network since 2019.
Anglian Water also continues to raise awareness of what should and shouldn't go down the drain through their "Just Bin It" campaign.
Mr Brailsford added: "We're asking everyone - businesses and customers alike - to take a moment and think before they flush or pour.
"If it's not pee, poo, or toilet paper, it belongs in the bin, not the drain.
"Together, through initiatives like this and everyday good habits, we can protect our homes, rivers, beaches, and the environment for future generations."