Kier began his career in European cinema and quickly became a hit in Hollywood after his role in "My Own Private Idaho," alongside Keanu Reeves and River Phoenix. The star racked up more than 250 credits to his name during his decades-long career in entertainment, including a longstanding partnership with director Lars von Trier in the late 80s. (RELATED: Country Singer Todd Snider Dead At 59)
Considered a cult icon, Kier collaborated with the likes of Andy Warhol and Madonna, before taking his final bow. The actor's partner, Delbert McBride, confirmed his death to Variety.
Kier's longtime friend, photographer Michael Childers, said he died at Eisenhower Hospital in Palm Springs, California in a Facebook post, but he did not disclose details surrounding his cause of death.
Kier starred in 1973's "Flesh for Frankenstein" and "Blood for Dracula," the following year -- both directed by Paul Morrissey and produced by Warhol.
His other notable credits include "The Third Generation," "Lili Marleen," "The Stationmaster's Wife," "Epidemic," "Europa," "Breaking the Waves," "Dancer in the Dark," "Dogville," "Melancholia" and "Nymphomaniac: Vol. II."
Kier also had a number of supporting roles in major Hollywood productions including "Ace Ventura: Pet Detective," and "Armageddon."
He also appeared in Madonna's book "Sex" in 1992, and was featured in her music videos for "Erotica" and "Deeper and Deeper" from her "Erotica" album.
The actor's final appearance was in the political thriller "The Secret Agent" where he played a Jewish Holocaust survivor.